induced pluripotent stem cells

While You Were at the Bench: Week 47

I hope everyone in the US had a great Thanksgiving.  I’ll keep this post short in case the Tryptophan is kicking in.

Over the past year, cancer researchers from Georgetown University have developed a technique to induce an indefinite proliferative state in primary mammalian epethelial cells without producing tumors that normally occur with embryonic stem cells or induced pluripotent stem cells.  These conditionally reprogrammed cells (CRC’s) were designed for screening cancer therapies, but this technique for creating adult stem-like cells is ideal for regenerative medicine.

In a big step forward for optogenetics, scientists at MIT have developed a 3D array of thin microwaveguides for delivering light to discrete brain regions for activating specific neurons.  This design allows for the independent control of hundreds of light sources for researchers to better understand the activity of entire neuronal circuits.

Turns out green algae is the vampire of the plant kingdom.  This is the first known plant species that secretes enzymes to break down cellulose from neighboring plants and assimilate it as an energy source for continued survival.  Since a major process for biofuel production is cellulose breakdown, green algae can now be used to expedite this process.

By pharmacologically inhibiting eIF4E expression, researchers at McGill University were able to reverse social behavior deficits in a mouse model of autism spectrum disorder.  While the inhibitory drug used is too toxic for human use, it does open new avenues of therapeutic targets for treating Autism.

Did the 2.5 billion dollar Curiosity Rover hit pay dirt?  (Sorry, I’ve been watching too much discovery channel.)  NASA is going to hold a press conference in two weeks to discuss an exciting discovery regarding a sample of Martian soil.  Internet buzz suggests organic material, but NASA is staying mute on the subject for now.

Have a Great Weekend!  I’m off to stimulate the economy.

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